Welcome to the EMPOWER series Clinical Care Toolkit, a source for cutting-edge information and resources for healthcare professionals who manage the treatment of patients with breast cancer. Oncology is a rapidly evolving field, and continuing education is vital for improving patient outcomes and providing personalized treatments. This toolkit is a source of up-to-date information on the impact of breast cancer, its pathophysiology particularly surrounding hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) metastatic disease, and the clinical profiles of targeted therapies. Additional resources are provided to help expand your knowledge and facilitate open communication with patients.